N-end brain
natriuretic peptide also called NT-proBNP fast kits ,
for heart failure detection is an important examination indexes. BNP also known
as BNP said the b-type natriuretic peptide, myocardial cells first synthesis of
108 amino acids BNP original, called proBNP (BNP precursor).
By heart muscle cells in the stimulation (for example, myocardial cell tensile), proBNP protease role in the following solutions for N-end brain natriuretic peptide (amino-terminal-proBNP or N t-proBNP) and biological activity hormone BNP. Two kinds of peptides have released into the blood circulating. Both source and waiting for the same Moore secretion.
Perlong medical equipment expert analysis, in the clinical, heart failure diagnosis from the point of the BNP and N-brain natriuretic peptide is no different. But there are no difference is impossible to statistics to the analysis of the two small differences. BNP and N-end brain natriuretic peptide tests in the diagnosis of acute and chronic HF with high diagnostic accuracy and has high correlation.
The removal of the body in different ways: the removal of the BNP mainly through and natriuretic peptides clear receptor (NPR-C) combined with and then was the swallow and lysosome degradation, and only a small amount of BNP through the kidney removed, when renal loss, neutral peptide chain enzymes (NEP) also can open the BNP ring structures and it cleared; N-end brain natriuretic peptide clear is the only way to glomerular filtration, kidney appears to lack the N-brain natriuretic peptide metabolic enormous influence.
Second, half life different: BNP's half-life is 22 minutes, and N-end brain natriuretic peptide half-life for 120 minutes. From the view point of clinical inspection, N-end brain natriuretic peptide in vitro are relatively stable, bring convenience to the test, but from clinical application point of view, more short half-life BNP more timely response patients condition changes, beneficial to the clinical monitoring the efficacy of treatment, the better to clinical application value.
Molecular structure is different: the molecular structure of the BNP there is a very important disulfide key connections consist of ring structures, but with natriuretic peptides receptors play biology active role; Nt proBNP medical test kits for a amylose structure, is losing biological activity of amino acids segment.
Two kinds of peptides have released into the blood circulating. Both source and waiting for the same Moore secretion. So, in theory, detection and N-the BNP brain natriuretic peptide clinical application results are the same. And from years of clinical results speaking, there is not much difference.
Article: from perlong medical (http://www.pl999.net)
Attention: if you want to copy this article , you must attach the website.
By heart muscle cells in the stimulation (for example, myocardial cell tensile), proBNP protease role in the following solutions for N-end brain natriuretic peptide (amino-terminal-proBNP or N t-proBNP) and biological activity hormone BNP. Two kinds of peptides have released into the blood circulating. Both source and waiting for the same Moore secretion.
Perlong medical equipment expert analysis, in the clinical, heart failure diagnosis from the point of the BNP and N-brain natriuretic peptide is no different. But there are no difference is impossible to statistics to the analysis of the two small differences. BNP and N-end brain natriuretic peptide tests in the diagnosis of acute and chronic HF with high diagnostic accuracy and has high correlation.
The removal of the body in different ways: the removal of the BNP mainly through and natriuretic peptides clear receptor (NPR-C) combined with and then was the swallow and lysosome degradation, and only a small amount of BNP through the kidney removed, when renal loss, neutral peptide chain enzymes (NEP) also can open the BNP ring structures and it cleared; N-end brain natriuretic peptide clear is the only way to glomerular filtration, kidney appears to lack the N-brain natriuretic peptide metabolic enormous influence.
Second, half life different: BNP's half-life is 22 minutes, and N-end brain natriuretic peptide half-life for 120 minutes. From the view point of clinical inspection, N-end brain natriuretic peptide in vitro are relatively stable, bring convenience to the test, but from clinical application point of view, more short half-life BNP more timely response patients condition changes, beneficial to the clinical monitoring the efficacy of treatment, the better to clinical application value.
Molecular structure is different: the molecular structure of the BNP there is a very important disulfide key connections consist of ring structures, but with natriuretic peptides receptors play biology active role; Nt proBNP medical test kits for a amylose structure, is losing biological activity of amino acids segment.
Two kinds of peptides have released into the blood circulating. Both source and waiting for the same Moore secretion. So, in theory, detection and N-the BNP brain natriuretic peptide clinical application results are the same. And from years of clinical results speaking, there is not much difference.
Article: from perlong medical (http://www.pl999.net)
Attention: if you want to copy this article , you must attach the website.
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